Deregulated MITF sumoylation: A route to melanoma
نویسندگان
چکیده
منابع مشابه
MITF pathway mutations in melanoma.
Microphthalmia-associated transcription factor (MITF), a key regulator of melanocyte development, belongs to the class of basic-helix ⁄ loop ⁄ helixleucine-zipper transcription factors. Microphthalmia-associated transcription factor regulates multiple genes related to melanin synthesis (e.g. TYR, DCT), control of apoptosis (e.g. BCL2) and cell cycle progression (e.g. p21, p16, CDK2, TBX2) as we...
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Melanoma is one of the most dangerous and lethal skin cancers, with a considerable metastatic potential and drug resistance. It involves a malignant transformation of melanocytes. The exact course of events in which melanocytes become melanoma cells remains unclear. Nevertheless, this process is said to be dependent on the occurrence of cells with the phenotype of progenitor cells - cells chara...
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The Microphthalmia associated transcription factor (Mitf) is an important regulator in melanocyte development and has been shown to be involved in melanoma progression. The current model for the role of Mitf in melanoma assumes that the total activity of the protein is tightly regulated in order to secure cell proliferation. Previous research has shown that regulation of Mitf is complex and inv...
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Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin, a polymer composed of several types of subunits formed from L-3,4dihydroxyphenylalanine. Melanin is deposited in subcellular particles called melanosomes. Cutaneous melanocytes originate from neural-crest progenitors that migrate to the skin during embryonic development. In the skin, melano...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2017
ISSN: 2372-3556
DOI: 10.1080/23723556.2017.1331154